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  1. Review

    Flow-regulated lymphatic vasculature development and signaling

    The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymp...

    Yingdi Wang and Michael Simons

    Vascular Cell 2014 6:14

    Published on: 9 July 2014

  2. Review

    In vitropre-vascularisation of tissue-engineered constructs A co-culture perspective

    In vitro pre-vascularization is one of the main vascularization strategies in the tissue engineering field. Culturing cells within a tissue-engineered construct (TEC) prior to implantation provides researchers wi...

    Jeremy Baldwin, Mélanie Antille, Ulrich Bonda, Elena M De-Juan-Pardo, Kiarash Khosrotehrani, Saso Ivanovski, Eugen Bogdan Petcu and Dietmar Werner Hutmacher

    Vascular Cell 2014 6:13

    Published on: 21 June 2014

  3. Research

    Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells

    The majority of triple-negative breast cancers (TNBCs) are basal-like breast cancers. However there is no reported study on anti-tumor effects of sunitinib in xenografts of basal-like TNBC (MDA-MB-468) cells. ...

    Edmund Chinchar, Kristina L Makey, John Gibson, Fang Chen, Shelby A Cole, Gail C Megason, Srinivassan Vijayakumar, Lucio Miele and Jian-Wei Gu

    Vascular Cell 2014 6:12

    Published on: 1 June 2014

  4. Research

    Effects of a novel cyclic RGD peptidomimetic on cell proliferation, migration and angiogenic activity in human endothelial cells

    Cyclic RGD peptidomimetics containing a bifunctional diketopiperazine scaffold are a novel class of high-affinity ligands for the integrins αVβ3 and αVβ5. Since integrins are a promising target for the modulation...

    Roberto Fanelli, Laura Schembri, Umberto Piarulli, Monica Pinoli, Emanuela Rasini, Mayra Paolillo, Marisa Carlotta Galiazzo, Marco Cosentino and Franca Marino

    Vascular Cell 2014 6:11

    Published on: 21 May 2014

  5. Research

    Angiogenic properties of dehydrated human amnion/chorion allografts: therapeutic potential for soft tissue repair and regeneration

    Chronic wounds are associated with a number of deficiencies in critical wound healing processes, including growth factor signaling and neovascularization. Human-derived placental tissues are rich in regenerati...

    Thomas J Koob, Jeremy J Lim, Michelle Massee, Nicole Zabek, Robert Rennert, Geoffrey Gurtner and William W Li

    Vascular Cell 2014 6:10

    Published on: 1 May 2014

  6. Methodology

    Development of immortalized mouse aortic endothelial cell lines

    The understanding of endothelial cell biology has been facilitated by the availability of primary endothelial cell cultures from a variety of sites and species; however, the isolation and maintenance of primar...

    Chih-Wen Ni, Sandeep Kumar, Casey J Ankeny and Hanjoong Jo

    Vascular Cell 2014 6:7

    Published on: 1 April 2014

  7. Research

    Embryonic rat vascular smooth muscle cells revisited - a model for neonatal, neointimal SMC or differentiated vascular stem cells?

    The A10 and A7r5 cell lines derived from the thoracic aorta of embryonic rat are widely used as models of non-differentiated, neonatal and neointimal vascular smooth muscle cells in culture. The recent discove...

    Eimear Kennedy, Roya Hakimjavadi, Chris Greene, Ciaran J Mooney, Emma Fitzpatrick, Laura E Collins, Christine E Loscher, Shaunta Guha, David Morrow, Eileen M Redmond and Paul A Cahill

    Vascular Cell 2014 6:6

    Published on: 15 March 2014

  8. Review

    Macrophages in solid organ transplantation

    Macrophages are highly plastic hematopoietic cells with diversified functions related to their anatomic location and differentiation states. A number of recent studies have examined the role of macrophages in ...

    Xinguo Jiang, Wen Tian, Yon K Sung, Jin Qian and Mark R Nicolls

    Vascular Cell 2014 6:5

    Published on: 11 March 2014

  9. Research

    Eribulin mesylate exerts specific gene expression changes in pericytes and shortens pericyte-driven capillary network in vitro

    Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B. Eribulin is a tubulin-binding drug and approved in many countries worldwide for treatment of cert...

    Sergei I Agoulnik, Satoshi Kawano, Noel Taylor, Judith Oestreicher, Junji Matsui, Jesse Chow, Yoshiya Oda and Yasuhiro Funahashi

    Vascular Cell 2014 6:3

    Published on: 1 March 2014

  10. Research

    Netrin-4 promotes mural cell adhesion and recruitment to endothelial cells

    Netrins are secreted molecules involved in axon guidance and angiogenesis. We previously showed that Netrin-4 acts as an anti-angiogenic factor by inhibiting endothelial cell (EC) functions. In this study, we ...

    Esma Lejmi, Ilyes Bouras, Serge Camelo, Marie Roumieux, Norbert Minet, Carole Leré-Déan, Tatyana Merkulova-Rainon, Gwennhael Autret, Catherine Vayssettes, Olivier Clement, Jean Plouët and Laurence Leconte

    Vascular Cell 2014 6:1

    Published on: 28 January 2014

  11. Review

    The role of tumor-associated macrophages in tumor vascularization

    Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophag...

    Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B Fisher and Xiang-Yang Wang

    Vascular Cell 2013 5:20

    Published on: 6 December 2013

    The Erratum to this article has been published in Vascular Cell 2014 6:2

  12. Review

    The effects of radiation on angiogenesis

    The average human body contains tens of thousands of miles of vessels that permeate every tissue down to the microscopic level. This makes the human vasculature a prime target for an agent like radiation that ...

    Peter Grabham and Preety Sharma

    Vascular Cell 2013 5:19

    Published on: 26 October 2013

  13. Research

    Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis

    Anti-angiogenesis is a validated strategy to treat cancer, with efficacy in controlling both primary tumor growth and metastasis. The role of the Notch family of proteins in tumor angiogenesis is still emergin...

    Sonia L Hernandez, Debarshi Banerjee, Alejandro Garcia, Thaned Kangsamaksin, Wei-Yi Cheng, Dimitris Anastassiou, Yasuhiro Funahashi, Angela Kadenhe-Chiweshe, Carrie J Shawber, Jan K Kitajewski, Jessica J Kandel and Darrell J Yamashiro

    Vascular Cell 2013 5:17

    Published on: 25 September 2013

  14. Research

    Cardiac angiogenesis directed by stable Hypoxia Inducible Factor-1

    The heterodimeric, oxygen-sensitive transcription factor Hypoxia Inducible Factor-1 (HIF-1) orchestrates angiogenesis and plays a key role in the response to ischemia and the growth of cancers.

    Chad B Walton, Jennifer Ecker, Cynthia D Anderson, Joel T Outten, Randall Z Allison and Ralph V Shohet

    Vascular Cell 2013 5:15

    Published on: 29 August 2013

  15. Research

    Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia

    Gene therapy stimulating the growth of blood vessels is considered for the treatment of peripheral and myocardial ischemia. Here we aimed to achieve angiogenic synergism between vascular endothelial growth fac...

    Agnieszka Jazwa, Mateusz Tomczyk, Hevidar M Taha, Elisa Hytonen, Mateusz Stoszko, Lorena Zentilin, Mauro Giacca, Seppo Yla-Herttuala, Costanza Emanueli, Alicja Jozkowicz and Jozef Dulak

    Vascular Cell 2013 5:13

    Published on: 1 July 2013

  16. Review

    Macrophages and angiogenesis in rheumatic diseases

    Angiogenesis plays a key role in several rheumatic diseases, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic sclerosis, systemic lupus erythematosus, and vasculitides. An imbal...

    Nicola Maruotti, Tiziana Annese, Francesco Paolo Cantatore and Domenico Ribatti

    Vascular Cell 2013 5:11

    Published on: 1 June 2013

  17. Research

    Human and mouse brain-derived endothelial cells require high levels of growth factors medium for their isolation, in vitro maintenance and survival

    Brain microvascular endothelial cells (BMVECs) constitute the primary limitation for passage of ions and molecules from the blood into the brain through the blood brain barrier. Numerous multi-step procedures ...

    Stefania Elena Navone, Giovanni Marfia, Sara Nava, Gloria Invernici, Silvia Cristini, Sergio Balbi, Simone Sangiorgi, Emilio Ciusani, Alessandra Bosutti, Giulio Alessandri, Mark Slevin and Eugenio Agostino Parati

    Vascular Cell 2013 5:10

    Published on: 14 May 2013

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