Cao Y: Antiangiogenic cancer therapy. Semin Cancer Biol. 2004, 14: 139-45. 10.1016/j.semcancer.2003.09.018.
Article
CAS
PubMed
Google Scholar
Cao Y: Tumor angiogenesis and molecular targets for therapy. Front Biosci. 2009, 14: 3962-73. 10.2741/3504.
Article
CAS
Google Scholar
Crawford Y, Ferrara N: VEGF inhibition: insights from preclinical and clinical studies. Cell Tissue Res. 2009, 335: 261-9. 10.1007/s00441-008-0675-8.
Article
CAS
PubMed
Google Scholar
Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, Feldmann HM, Liang Z, Zhu Z, Nedergaard J, Cannon B, Cao Y: Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 2009, 9: 99-109. 10.1016/j.cmet.2008.11.009.
Article
CAS
PubMed
Google Scholar
Xue Y, Religa P, Cao R, Hansen AJ, Lucchini F, Jones B, Wu Y, Zhu Z, Pytowski B, Liang Y, Zhong W, Vezzoni P, Rozell B, Cao Y: Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome. Proc Natl Acad Sci USA. 2008, 105: 18513-8. 10.1073/pnas.0807967105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996, 380: 435-9. 10.1038/380435a0.
Article
CAS
PubMed
Google Scholar
Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW: Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 1996, 380: 439-42. 10.1038/380439a0.
Article
CAS
PubMed
Google Scholar
Ferrara N: Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2009, 29: 789-91. 10.1161/ATVBAHA.108.179663.
Article
CAS
PubMed
Google Scholar
Kamba T, McDonald DM: Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer. 2007, 96: 1788-95. 10.1038/sj.bjc.6603813.
Article
PubMed Central
CAS
PubMed
Google Scholar
Stockmann C, Doedens A, Weidemann A, Zhang N, Takeda N, Greenberg JI, Cheresh DA, Johnson RS: Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature. 2008, 456: 814-8. 10.1038/nature07445.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ: VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med. 2006, 12: 793-800. 10.1038/nm1428.
Article
CAS
PubMed
Google Scholar
Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L: Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature. 2001, 414: 550-4. 10.1038/35107085.
Article
CAS
PubMed
Google Scholar
Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992, 359: 843-5. 10.1038/359843a0.
Article
CAS
PubMed
Google Scholar
Nagy JA, Chang SH, Dvorak AM, Dvorak HF: Why are tumour blood vessels abnormal and why is it important to know?. Br J Cancer. 2009, 100: 865-9. 10.1038/sj.bjc.6604929.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L, Wu Y, Hicklin D, Zhu Z, Hackett NR, Crystal RG, Moore MA, Hajjar KA, Manova K, Benezra R, Rafii S: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med. 2001, 7: 1194-201. 10.1038/nm1101-1194.
Article
CAS
PubMed
Google Scholar
Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, Hicklin DJ, Chaplin D, Foster FS, Benezra R, Kerbel RS: Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science. 2006, 313: 1785-7. 10.1126/science.1127592.
Article
CAS
PubMed
Google Scholar
Bjorndahl MA, Cao R, Burton JB, Brakenhielm E, Religa P, Galter D, Wu L, Cao Y: Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis. Cancer Res. 2005, 65: 9261-8. 10.1158/0008-5472.CAN-04-2345.
Article
PubMed
Google Scholar
Cursiefen C, Chen L, Borges LP, Jackson D, Cao J, Radziejewski C, D'Amore PA, Dana MR, Wiegand SJ, Streilein JW: VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest. 2004, 113: 1040-50.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hong YK, Lange-Asschenfeldt B, Velasco P, Hirakawa S, Kunstfeld R, Brown LF, Bohlen P, Senger DR, Detmar M: VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J. 2004, 18: 1111-3.
CAS
PubMed
Google Scholar
Nagy JA, Vasile E, Feng D, Sundberg C, Brown LF, Detmar MJ, Lawitts JA, Benjamin L, Tan X, Manseau EJ, Dvorak AM, Dvorak HF: Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med. 2002, 196: 1497-506. 10.1084/jem.20021244.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cao Y: Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci Signal. 2009, 2: re1-10.1126/scisignal.259re1.
Article
PubMed
Google Scholar
Caunt M, Mak J, Liang WC, Stawicki S, Pan Q, Tong RK, Kowalski J, Ho C, Reslan HB, Ross J, Berry L, Kasman I, Zlot C, Cheng Z, Le Couter J, Filvaroff EH, Plowman G, Peale F, French D, Carano R, Koch AW, Wu Y, Watts RJ, Tessier-Lavigne M, Bagri A: Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell. 2008, 13: 331-42. 10.1016/j.ccr.2008.01.029.
Article
CAS
PubMed
Google Scholar
Pan Q, Chanthery Y, Liang WC, Stawicki S, Mak J, Rathore N, Tong RK, Kowalski J, Yee SF, Pacheco G, Ross S, Cheng Z, Le Couter J, Plowman G, Peale F, Koch AW, Wu Y, Bagri A, Tessier-Lavigne M, Watts RJ: Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell. 2007, 11: 53-67. 10.1016/j.ccr.2006.10.018.
Article
CAS
PubMed
Google Scholar
Cao Y, Zhong W, Sun Y: Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance. Semin Cancer Biol. 2009
Google Scholar
Collins TS, Hurwitz HI: Targeting vascular endothelial growth factor and angiogenesis for the treatment of colorectal cancer. Semin Oncol. 2005, 32: 61-8. 10.1053/j.seminoncol.2004.09.026.
Article
CAS
PubMed
Google Scholar
Eriksson A, Cao R, Pawliuk R, Berg SM, Tsang M, Zhou D, Fleet C, Tritsaris K, Dissing S, Leboulch P, Cao Y: Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers. Cancer Cell. 2002, 1: 99-108. 10.1016/S1535-6108(02)00028-4.
Article
CAS
PubMed
Google Scholar
Ledford H: Drug markers questioned. Nature. 2008, 452: 510-1. 10.1038/452510a.
Article
CAS
PubMed
Google Scholar