Figure 4

Histology and vasculature of liver and spleen treated with VEGFR blockades. Spleen (A-C) and liver (D-F) tissue sections from buffer- (A, D, and G), anti-VEGFR1- (B, E and H), or anti-VEGFR2-(C, F and I) treated T241-VEGF-bearing mice were stained with H&E (A-F) or anti-CD31 (G-I). Arrows in panels of G-I indicate microsinusoidal vasculatures in liver sections. CV = central vein. Bar = 50 μm.