Figure 4From: Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factorMacrophage recruitment is altered by BV and SC236 treatment. Distribution of macrophages was examined using the mouse macrophage marker F4/80 (Figure 4A). Morphologically, F4/80 appeared to be increased in BV- and BV+SC236-treated tumors, with somewhat more irregularity in the latter. Quantified F4/80(+) signal was significantly increased in BV- and SC236+BV-treated groups versus controls (Figure 4B). TNFα-immunopositive cell distribution appeared similar to the patterns for F4/80 signal (Figure 4C). The M2 marker arginase was detected in cells primarily in necrotic regions, which did not change with treatment (not shown).Back to article page