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Table 1 Pharmacokinetic parameters of VEGF 121 and VEGF PADS

From: Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis

    Free VEGF VEGF PADS
Central compartment volume of distribution V c (L) 0.013 ± 0.005 0.013 ± 0.003
Plasma clearance Cl (L min-1) 0.0008 ± 0.0003 0.0004 ± 0.0004
Area under curve AUC (nmol min L-1) 3,863.8 ± 1,444.6 5,059.0 ± 528.5
Distribution half life t 1/2 dist (min) 8.6 7.2
Terminal half life t 1/2 term (min) 30.2 52.4