Figure 1
From: Flow-regulated lymphatic vasculature development and signaling
Fluid flow in lymphatic vasculature development in mice. (A) Flow triggers lymphatic valve development. At approximately embryonic day (E)16.0, lymph flow induces Cx37 expression and activates calcineurin/NFATc1 signaling in lymphatic-valve-forming cells initiating luminal valve development. (B) Fluid flow plays a role in lymphatic fate maintenance. In mice, loss of Slp-76 results in shunt formation between blood and lymphatic vessels in mesentery and, therefore mixing of blood and lymphatic circulation. The presence of blood flow in lymphatic vessels in Slp-76 null mice causes the change of lymphatic fate to a venous identity.