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Figure 4 | Vascular Cell

Figure 4

From: Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells

Figure 4

Sunitinib at 1 μmol/L significantly inhibited the invasion of MDA-MB-468 cells invasion or migration in BD BioCoat Matrigel Invasion Chamber, compared to the control group (34 ± 4 vs. 61 ± 8 cell number/mm2; P < 0.01; n = 6). The images showed the migrated MDA-MB-468 cells (A) (B) indicated that sunitinib at 5 μmol/L significantly increased apoptosis of cultured MDA-MB-468 cells. The images were TUNEL staining of sunitinib-treated or the control MDA-MB-468 cells. Anuexin V-positive cells were observed in sunitinib-treated group, compared to the control group (19.4% vs. 4.4% of Anuexin V-positive cells; n = 6; P < 0.01), respectively.

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Vascular Cell

ISSN: 2045-824X

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