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Table 2 Real time PCR analysis of the expression of mRNA for the integrin subunits α v , β 3 and β 5 in HUVEC cultured for 5 h in basal conditions and with VEGF, EGF, IGF, and FGF, alone (control) or in the presence of 1 μM cyclo [DKP-RGD] 1

From: Effects of a novel cyclic RGD peptidomimetic on cell proliferation, migration and angiogenic activity in human endothelial cells

Subunit

control

+ cyclo[DKP-RGD] 1

 

2 -Δct ×10 2

2 -Δct ×10 2

Ratio vs Control

P vs Control

A. Basal conditions

αv

6.65 ± 6.41

6.59 ± 5.24

1.32 ± 0.57

0.944

β3

0.89 ± 0.87

0.91 ± 0.76

1.08 ± 0.27

0.928

β5

1.36 ± 1.18

1.52 ± 1.34

1.08 ± 0.07

0.225

B. With VEGF, EGF, IGF, and FGF

αv

13.31 ± 12.80

15.09 ± 10.66

1.28 ± 0.42

0.494

β3

1.15 ± 1.07

1.41 ± 1.07

1.43 ± 0.35

0.288

β5

1.23 ± 1.25

1.31 ± 1.13

1.34 ± 0.46

0.461

  1. Data are means ± SD of 3 separate experiments.
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Vascular Cell

ISSN: 2045-824X

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