Figure 1

A, AGExt (0–56 mg/ml) inhibition of dimer and trimer production in BSA exposed to high glucose (0.5 M; a-b, controls) in vitro for 21 days (c-h; 0, 7, 14, 28, 42, 56 mg/ml). B, Lysozyme incubated in the absence (lane a) or presence of 0.5 M glucose (b–i) for 35 days and the effect of 0, 7, 14, 28, 42, 56, 70 and 84 mg/ml of AGExt on dimerization. Arrows indicate a significant reduction in dimmer and trimer formation in the presence of AGExt.