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Figure 6 | Vascular Cell

Figure 6

From: Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential

Figure 6

Priming of AD-MSCs and HNDFs with TNFα induce an opposite effect on RANTES and MCP-1 release by U937. AD-MSCs and HNDFs were primed for 12 hrs with TNFα 25 ng/ml. Thereafter cells were washed and further incubated for 24 hrs. At the end of incubation, CMs were collected from primed AD-MSCs (P-AD-MSCs-CM) and primed HNDFs (P-HNDFs-CM) and tested on U937 chemokines production. Note that, while the addition of P-AD-MSCs-CM to U937 completely blocked RANTES and MCP-1 release, in an opposite manner, P-HNDFs-CM improved their release. The columns in the figure are mean ± SD of two independent experiments run in triplicate. ° p < 0.05 and °° p < 0.01 versus HNDF-CM, *p < 0.05 and **p < 0.01 versus AD-MSCs-CM, + p < 0.05 and ++ p < 0.01 versus CTRL.

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Vascular Cell

ISSN: 2045-824X

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