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Figure 5 | Vascular Cell

Figure 5

From: Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential

Figure 5

Addition of AD-MSCs-CM, but not HNDFs-CM, to U937 blocked production of RANTES and MCP-by U937. ELISA-kits were used to quantify the production of RANTES and MCP-1 by U937 under basal culture conditions, in the presence of inflammatory stimuli LPS(1 μg/ml) (A and B) and TNFα (25 ng/ml) (C and D) and in the presence of AD-MSCs-CM and HNDFs-CM. In (A) RANTES and in (B) MCP-1 production are blocked in a dose dependent manner by the addition of AD-MSCs-CM but not by HNDFs-CM under basal or in the presence of LPS. Similarly, in (C) RANTES and in (D) MCP-1 release is inhibited by the addition of AD-MSCs-CM to U937 stimulated or not with TNFα for 12 hrs. The columns in the figure are mean ± SD of three independent experiments run in triplicate. *p < 0.05 and **p < 0.01 versus CTRL.

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Vascular Cell

ISSN: 2045-824X

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