Table 1 Comparison Wnt-mediated regulation of the EAhy926 immortalized cell line and HUVECs.
Human endothelial immortalized cell line EAhy926, treated with Wnt3a (our results) | Primary HUVECs, treated with Wnt3a [17] |
|---|---|
Increase of nuclear β-catenin | Stabilization of total cellular β-catenin |
Activation of Wnt/β-catenin throughput | Induction of DVL3 phosphorylation |
Up-regulation of full length Lef1 | Data are not available |
Increase in proliferation (MTT) after Lef1 transfection | Increase in proliferation (BrdU incorporation) |
Elevation of MMP2 | No change in MMP-1 |
Lef1 siRNA induced inhibition of MMP2 response | Data are not available |
Increase of invasion | Increase of migration |
Data are not available | No effect on survival |