Figure 1
From: Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
Effects of Dll4-Notch inhibition on tumor angiogenesis. Blockade of Dll4-Notch signaling in endothelial cells leads to tumor vessel abnormalization characterized by increased tumor vessel sprouting and decreased vascular perfusion. It is currently not clear whether hypersprouting leads to decreased tumor perfusion (left hand axis) or decreased perfusion leads to hypersprouting (right hand axis), or whether both occur in parallel. The overall effect of Dll4-Notch blockade is decreased tumor perfusion and reduced tumor growth.