Figure 1From: Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2Effect of 3ABA on in vitro chemoinvasion. Starved HUVEC were plated in the upper Boyden chamber and treated without and with 3ABA (50 μM) for 6 h. FGF2 was used in the lower compartment as chemoattractant. FGF2 induced a significative increase (+63%) of cells ability to invade Matrigel, compared to unstimulated cells. Treatment with 3ABA significantly inhibited both FGF2-stimulated and spontaneous cell invasiveness of about 55%. Values are expressed as the number of cells migrated through pores, and are mean ± SEM of three experiments. Multiple comparisons were performed by the Student-Newman-Keuls test, after Kruskal-Wallis analysis. (* p < 0.05 compared to control; # p < 0.05 compared to FGF2 stimulated cells).Back to article page