Figure 9
From: A deficiency of uPAR alters endothelial angiogenic function and cell morphology
Effect of a uPAR deficiency on angiogenesis in an in vivo Matrigel assay: Matrigel containing 10 ng/ml VEGF was implanted s.c. and recovered on day 14 after implantation, fixed, and stained for smooth muscle α-actin to observe capillary formation. (A) Representative image of Matrigel implant excised from WT mouse shows the presence of robust and well-developed capillaries (arrows). (B) Representative image of Matrigel implant excised from uPAR-/- mouse shows the presence of several truncated structures that have not been organized to form a functional capillary (arrows).