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Figure 3 | Journal of Angiogenesis Research

Figure 3

From: 25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner

Figure 3

Long-term exposure to 25-OHC is toxic to ECs. Exposure to 25-OHC past 60 hours caused the cells to undergo cell death. Levels of EC death due to 25-OHC was measured at 72 hours by ELISA assay quantifying DNA fragmentation. BmAECs were significantly more susceptible to cell death induced by prolonged 25-OHC exposure than either bmVECs or bmLECs. Celecoxib at 5 μM did not reverse the cell death.

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Vascular Cell

ISSN: 2045-824X

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