Nano to micro delivery systems: targeting angiogenesis in brain tumors

Vascular Cell

Table 1 FDA approved or under clinical trails drugs for brain tumors therapy

Drug	FDA approved for brain tumors/Brain clinical trails	Approved routes of administration (Brain tumors & other disorders)	Drug delivery platforms in research for approved drugs
Temozolomide	Approved	Oral	Intracerebral Biodegradable gel matrices/Polymer nanoparticles
Procarbazine	Approved	Oral	-
lomustine	Approved	Oral	Liposomes/Microcapsules
Vincristine	Approved	IV	Intra-arterially
Carmustine	Approved	IV/Oral/Wafer	CED/Polymer microchips and microspheres
Carboplatin	Approved	IV	CED/Intracerebral/Intraarterial/Liposomes
Bevacizumab	Approved	IV	Intra-arterial
Doxorubicin	Phase I/II/III	injection;liposomal *	-
Imatinib mesylate	Phase I/II/III	Oral; Intravenous *	-
Cisplatin	Phase I/II/III	Injection *	-
Topotecan	Phase I/II/III	Injection; Oral *	-
Interferon-alpha	Phase I/II	Injection; Subcutaneous; Oral *	-
Paclitaxel	Phase I/II	Intravenous; Injection *	-
Arsenic trioxide	Phase I/II	Injection *	-

ISSN: 2045-824X