Figure 1

The effects of R1-mAb and R2-mAb on the serum ALT level and survival rate of rats with Gal-N+LPS-induced acute hepatic failure. A: The effects of R1-mAb and R2-mAb on the serum ALT level following Gal-N+LPS intoxication. Injection of Gal-N+LPS resulted in a moderate increase of the serum ALT level at 24 h. Both R1-mAb and R2-mAb significantly augmented the elevation of ALT, and the elevation magnitude with R2-mAb was significantly higher than with R1-mAb. B: The survival rate 24 h after intoxication in relation to the peak of ALT. The survival rate in the R2mAb-treated animals was 70%, whereas no animals died in the other groups. No mice died after 24 h in all groups. Cont: Control IgG-treated mice (G1). Mice in group 2 (G2: Gal-N) simultaneously received Gal-N (375 mg/kg), LPS (50 μg/kg), and the control IgG intraperitoneally at 0 h. Instead of the control IgG, animals in group 3 (G3: R1) and group 4 (G4: R2) received the equal amounts of R1mAb or R2mAb intraperitoneally at 0 h, respectively. Each points in Fig. 1A represents the mean ± SD. *: Statistically significant differences between the experimental groups (p < 0.05).