Table 2 Mammalian Notch receptors and ligands involved in vascular development and disease

Notch1

Proper vascular development; Postnatal neovascularization

[13, 31, 32]

Notch3

Maturation of vascular smooth muscle cells

[44]

Notch4

Null mice show normal vascular development; Notch1; Notch4 mutant mice have severe vascular defects; Gain-of-function experiments show vascular abnormalities in development and postnatal life

[13, 33, 34]

Notch ligands

Jagged1

Dispensable for arterial specification; Formation of hematopoietic stem cells from the aorta; Smooth muscle differentiation and maturation; Proangiogenic regulation

[21, 39–41, 52]

Dll1

Maintenance of arterial identity; Arterial smooth muscle differentiation; Postnatal arteriogenesis

[19, 38]

Dll4

Arterial specification; Tip cell and stalk cell selection during sprouting angiogenesis; Regulation of tumor angiogenesis

[23, 25, 35–37, 46–52, 55, 56]