Table 3 Alterations in biomarker parameters induced by chemotherapy in breast cancer patients
Procoagulant/adhesion molecule | Pre-chemo [n] | Day 1 (post) [n] | Day 4 (post) [n] | Day 8 (post) [n] | 3 months (post) [n] | Trend over time (repeated meas, GG) |
|---|---|---|---|---|---|---|
sVEGF μg/ml, geometric mean (CI) | 218.0 (190.3-249.6) [121] | 203.4 (176.5-234.4) [114] | 158.3 (136.6-183.4) [114] | 154.3 (132.5-179.8) [116] | 236.7 (205.0-273.4) [109] | p < 0.001 |
pVEGF μg/ml, geometric mean (CI) | 16.4 (14.2-18.8) [120] | 14.9 (13.2-16.9) [115] | 16.3 (14.0-18.0) [112] | 20.5 (18.3-13.0) [114] | 21.6 (18.8-24.9) [106] | p < 0.001 |
Platelet count × 109/l Mean (CI) | 314 (298.4-330.9) [123] | 306 (287.2-325) [99] | 263.3 (249.7-276.8) [108] | 242.3 (227.3-257.2) [117] | 310 (285.0-334) [112] | P < 0.001 |
Platelet VEGF VEGF μg/ml per platelet × 109 median (range) [n] | 0.62 (0.54-0.72) [120] | 0.61 (0.52-0.71) [99] | 0.51 (0.43-0.61) [108] | 0.53 (0.45-0.64) [114] | 0.72 (0.62-0.83) [106] | P < 0.001 |