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Fig. 2 | Vascular Cell

Fig. 2

From: Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice

Fig. 2

Impaired Arterial Network in MK2-deficient mice. a Normal number of central arteries in MK2-WT and -KO mice. SMA-staining. Scale bar: 400 μm. b Arterial branchpoints. KO have less branchpoints especially in higher orders of junctions. SMA-staining. Scale bar: 200 μm. c Reduced total arterial area in MK2-KO mice. Images were converted from SMA-stained retinas to generate a black-and-white-image. d Isolated SMC from WT and MK2-KO mice, immunofluorescence. Pronounced flattening of SMC in KO mice as a surrogate of dedifferentiation. Scale bar: 50 μm. e RT-PCR of SMC marker genes. f Western blotting for the same targets as in (e). Both e and f demonstrate reduced expression of prototypical SMC marker genes in MK2-KO mice. P indicates postnatal day, w indicates weeks. * = p < 0.05, ** = p < 0.01

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