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Fig. 6 | Vascular Cell

Fig. 6

From: Angiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells

Fig. 6

Angiogenic properties of LG and LG-MSCs. The angiogenic properties of LG and LG-MSCs were investigated by testing their CM. In (a) the effect of LG-CM and LG-MSCs-CM on HUVECs proliferation. EGM medium was used as positive control for proliferation, EGM medium without growth factors the negative control (CTRL) (* p < 0.05; ** p < 0.01 versus CTRL). In (b) the quantification of cord formations on MTG by HUVECs under the influence of LG-CM and LG-MSCs-CM at 12 h and at 24 h in (c) (* p < 0.05; ** p < 0.01 versus CTRL). In (d) the analysis of angiogenic molecules present in the secretome of LG-CM in comparison to LG-MSCs-CM. MMP2 was significantly reduced in LG-CM, while ANG-1 and ANG-2 were increased (* p < 0.05; ** p < 0.01 versus LG-MSCs-CM). In (e) and in (f) the effect of LG-CM and LG-MSCs-CM on the expression of HUVEC ICAM-1 and VCAM-1 respectively (* p < 0.05; ** p < 0.01 versus CTRL; °p < 0.05, °° p < 0.01 versus TNFα treatment)

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Vascular Cell

ISSN: 2045-824X

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