Figure 6
From: Solenopsin A and analogs exhibit ceramide-like biological activity
A model for the effect of Ceramide and Solenopsin on cell function. Ceramide (Cer.) and solenopsin (Sol.) derivatives inhibit the AKT pathway by translocating PTEN from non-raft regions into the rafts. Ceramide and solenopsin also increase mitochondrial ROS production, reduce oxygen consumption (OCR), and induces autophagosome formation.