Figure 2
From: Solenopsin A and analogs exhibit ceramide-like biological activity
Assessment of anti-proliferative activity for solenopsin and analogs S11-S15. The anti-proliferative effect of (+)-solenopsin A ((+) Sol. A), (−)-solenopsin A ((−) Sol. A), ceramide C2, and solenopsin analogs S11-S15 were evaluated in (a) A375 cells, (b) SVR cells, and (c) A2058 cells. 50,000 cells/well were plated and treated for 24 h with each compound. The first DMSO bar in each chart serves as control for (+)-solenopsin A, (−)-solenopsin A, and ceramide C2. The second DMSO bar is the control for S11-S15. The displayed data are an average of four experiments ± s.d.