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Table 1 Effects of γ-actin knockdown on random motility parameters

From: γ-Actin plays a key role in endothelial cell motility and neovessel maintenance

Parameters

Control siRNA

γ-actin siRNA

% change

Average cell velocity (μm/min)

0.53 ± 0.03

0.37 ± 0.03

−30 ± 5 %**

Persistence time (min)

6.3 ± 0.3

8.6 ± 0.6

+36 ± 7 %*

Random motility coefficient (μm2/min)

0.90 ± 0.05

0.55 ± 0.07

−38 ± 8 %**

  1. At least 25 individual cells were analysed per view field using the persistence random-walk model [19]. Values are average of four individual experiments ± SEM. Statistics were calculated by comparing control and γ-actin siRNA-treated cells: *, p < 0.05; **, p < 0.01.