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Figure 5 | Vascular Cell

Figure 5

From: Lymphangiogenesis and angiogenesis during human fetal pancreas development

Figure 5

Association of lymphatic vessels with smooth muscle cells and basement membrane formation during human pancreatic development. (A) Pancreata at W12, W14.5 and W17 immunostained for podoplanin (PDPN) and smooth muscle actin (ACTA2). PDPN-positive lymphatic vessels (white arrows) showed no association with smooth muscle cells up to W12 in contrast to arteries (white asterisks). From W14.5 onwards, PDPN-positive lymphatic vessels (white arrow) were sparsely covered with smooth muscle cells. (B) Pancreata at W11 and W17 immunostained for PDPN and COL4A. PDPN-positive lymphatic vessels (white arrows) were covered with a discontinuous basement membrane, whereas blood vessels (white asterisks) were covered by a continuous basement membrane. Scale bars: 30 μm.

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