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Figure 8 | Vascular Cell

Figure 8

From: Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury

Figure 8

Myh11 -tagged medial SMCs give rise to the mature neointima following carotid ligation. Tissues were harvested 28 days following carotid ligation of 5-week old male Myh11 creER(T2)-/+ mTmG-/+ mice that were previously Treated with Tamoxifen (TAM) or corn oil(CO) as indicated. In the upper two panels the control and injured carotid arteries from the same mouse are shown. The neointima, media and adventitia (adv) are indicated. Images are representative of those obtained from 7 tamoxifen treated mice (Mice numbers 1,7,2,3 in Table 1, as indicated). Arrows point to examples of endothelial cell nuclei. The image in the lower right hand panel is of an injured vessel obtained from a corn oil control treated mouse. The arrow-head in this image points to an mEGFP positive cell within the medial layer. All images are shown at the same magnification with the scale bars representing 50 μm.

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Vascular Cell

ISSN: 2045-824X

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