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Figure 6 | Vascular Cell

Figure 6

From: Limitations of the dorsal skinfold window chamber model in evaluating anti-angiogenic therapy during early phase of angiogenesis

Figure 6

Vascular structure after Ang-2 inhibition. Immunohistochemical analysis of vascular structure at study endpoint. (A) Normal vasculature with pericyte coverage. (B) Tumor vasculature without pericyte coverage. Scale bar, 46 μm. (C) Ang-2 inhibition led to increased number of vessels that maintained pericyte coverage. Line, median; *, p < 0.05; Mann- Whitney U-Test. Representative images of each group. White arrows show pericyte covered vessels; yellow arrow shows vessels without pericyte coverage. Red, MECA (endothelium); green, NG2 (pericyte); blue, DAPI. Images taken with Zeiss Axioplan Imaging2 microscope with 20× objective; scale bar = 140 μm.

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Vascular Cell

ISSN: 2045-824X

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