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Figure 6 | Vascular Cell

Figure 6

From: Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells

Figure 6

Western blot analysis indicated that sunitinib at 1 μmol/L significantly increased the expression of Notch-1 at 24, 48, and 72 hours of the treatment in cultured MDA-MB-468 cells (A) and MDA-MB-231 cells (B), respectively. In cultured MDA-MB-468 cells, compared to the control group, respectively (n = 4; P < 0.01), in which the densitometry ratio of Notch1/β-actin in sunitinib-group was significantly (P < 0.01) increased by 2.0-fold, 2.5-fold, and 5.7-fold at 24, 48, and 72 hours than the control group, respectively. But, sunitinib at 0.1 μmol/L had no effect on the expression of Notch-1. The similar results were also observed in cultured MDA-MB-231 cells.

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