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Figure 3 | Vascular Cell

Figure 3

From: Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells

Figure 3

VEGF protein was highly expressed in cultured MDA-MB-468 cells in which sunitinib-treatment caused a dose-related inhibition on the proliferation. Figure A showed that VEGF protein was more expressed in MDA-MB-468 cells than MDA-MB-231 cells (>3 fold, P < 0.01, n = 6; 10257 ± 212 vs. 3408 ± 136 pg/mg) or MCF-7 cells (>30 fold, P < 0.01, n = 6; 10257 ± 212 vs. 336 ± 15 pg/mg). 3H-thymidine incorporation assay indicated that sunitinib-treatment caused a dose-related inhibition on proliferation in cultured MDA-MB-468 cells, by 24% at 1 μmol/L, by 41% at 5 μmol/L, and 59% at 10 μmol/L, compared to the control group (n = 6; P < 0.01), respectively (B).

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Vascular Cell

ISSN: 2045-824X

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