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Figure 2 | Vascular Cell

Figure 2

From: EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression

Figure 2

Oral EGCG at 50–100 mg/kg/d in drinking water significantly reduced intratumoral microvessel density (Panel A: 109 ± 20 vs. 156 ± 12 microvessel #/mm^2; P < 0.01), plasma VEGF levels (Panel B; 26.48 ± 3.76 vs. 40.79 ± 3.5 pg/ml; P < 0.01), and tumor VEGF expression (Panel B; 45.72 ± 1.4 vs. 59.03 ± 3.8 pg/mg; P < 0.01) over the control, respectively in mice (n = 8). The digital images show CD31 immunohistochemistry staining in OCT-embedded cryosections of mouse breast cancer tumors obtained from a control (Figure 2A) or EGCG-treated (Figure 2A) mouse.

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Vascular Cell

ISSN: 2045-824X

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