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Table 1 Fold changes in mRNA expression levels of genes in HEMECs compared to HDMVECs

From: Gene expression analysis reveals marked differences in the transcriptome of infantile hemangioma endothelial cells compared to normal dermal microvascular endothelial cells

Gene symbol

Gene name

Accession number

FC

CTAG2

Cancer/testis antigen 2

NM_020994.3

11.6

IL13RA2

Interleukin 13 Receptor, alpha 2

NM_000640.2

10.7

IFI27

Interferon, alpha-inducible protein 27

NM_005532.3

8.3

TPM2

Tropomyosin 2 (beta)

NM_213674.1

7.8

RPL14

Ribosomal protein L14

NM_001034996.1

6.6

CCNA1

Cyclin A1

NM_003914.3

6.6

RGS5

G-protein signaling 5 regulator

NM_003617.3

6.0

FBN2

Fibrillin 2

NM_001999.3

5.9

D4S234E

DNA segment on chromosome 4 (unique)

NM_001040101.1

5.5

BST2

Bone marrow stromal cell antigen 2

NM_004335.2

5.1

QPCT

Glutaminyl-peptide cyclotransferase

NM_012413.3

4.8

TNFSF4

Tumor necrosis factor (ligand) superfamily, member 4

NM_003326.3

4.6

RGS5

Regulator of G-protein signaling 5

NM_003617.3

4.6

SPOCK1

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1

NM_004598.3

4.6

SNHG8

Small nucleolar RNA host gene 8 (non-protein coding)

NR_003584.3

4.6

ANTXR1

Anthrax toxin receptor 1

NM_032208.2

4.5

CHST1

Carbohydrate sulfotransferase 1

NM_003654.5

4.5

MPZL2

Myelin protein zero-like 2

NM_005797.3

4.4

HEY2

Hairy/enhancer-of-spilt related with YRPW motif 2

NM_012259.2

4.3

SLITRK4

SLIT and NTRK-like family, member 4

NM_173078.3

4.2

SHISA2

Shisa homolog 2

NM_001007538.1

4.0

LRRC17

Leucine rich repeat containing 17, TV2

NM_005824.2

3.9

NUDT11

Nudix-type motif 11

NM_018159.3

3.8

RNASE1

Ribonuclease, Rnase A family, 1, TV1

NM_198235.2

3.7

SERPINE2

Serpin peptidase inhibitor, clade E, member 2

NM_006216.3

3.6

LIPG

Lipase, endothelial

NM_006033.2

3.4

PCSK5

Proprotein convertase subtilisin/kexin type 5

NM_006200.3

3.4

LPXN

Leupaxin

NM_004811.2

3.3

CXCR4

Chmeokine (C-X-C motif) receptor 4, TV2

NM_003467.2

3.2

TMEM200A

Transmembrane protein 200A

NM_052913.2

3.1

CXCR4

Chemokine (C-X-C motif) receptor 4, TV1

NM_001008540.1

3.1

RAB34

RAB34, member RAS onogene family

NM_031934.5

3.0

DPYSL3

Dihydropyrimidinase-like 3

NM_001387.2

2.9

FBXL13

F-box and leucine-rich repeat protein 13

NM_145032.3

2.9

PNMA2

Paraneoplastic Ma antigen 2

NM_007257.5

2.9

LOC440354

LOC440354

NR_002473.2

2.9

NLGN1

Neuroligin 1

NM_014932.2

2.8

DDIT4

DNA-damage-inducible transcript 4

NM_019058.2

2.8

PFN2

Profilin 2

NM_053024.3

2.8

GABBR2

Gamma-aminobutyric acid B receptor, 2

NM_005458.7

2.8

MEIS2

Meis homeobox 2

NM_172315.2

2.7

PMEPA1

Prostate transmembrane protein, androgen induced 1

NM_199169.2

2.7

LOC647307

LOC647308

XR_039752.1

2.7

PLEK2

Pleckstrin 2

NM_016445.1

2.7

CARD11

Caspase recruitment domain family, member 11

NM_032415.4

2.6

SNORD13

Small nucleolar RNA, C/D box 13, small nucleolar RNA

NR_003041.1

2.6

GFPT2

Glutamine-fructoce-6-phosphate transaminase 2

NM_005110.2

2.6

FAP

Fibroblast activation protein, alpha

NM_004460.2

2.6

OCIAD2

OCIA domain containing 2, TV2

NM_152398.2

2.5

F2RL1

Coagulation factor II receptor-like 1

NM_005242.4

2.5

DSTYK

Dual serine/threonine and tyrosine protein kinase

NM_199462.2

2.5

LOC649497

LOC649498

XM_938576.1

2.5

LOC654194

LOC654195

XM_942669.1

2.5

NYNRIN

NYN domain and retroviral integrase containing

NM_025081.2

2.5

LOC387763

LOC387764

XM_941665.2

2.5

COL8A1

Collagen, type VIII, alpha 1

NM_020351.3

2.5

MGC39900

MGC39901

XM_936687.1

2.4

LTBP2

Latent transforming growth factor beta binding protein 2

NM_000428.2

2.4

RNASE1

Ribonuclease, Rnase A family, 1, TV3

NM_198232.2

2.4

IFI27L2

Interferon, alpha-inducible protein 27-like 2

NM_032036.2

2.4

SOX4

SRY (sex determining region Y)-box4

NM_003107.2

2.4

LRRC17

Leucine rich repeat containing 17, TV1

NM_001031692.2

2.3

DSE

Dermatan sulfate epimerase

NM_013352.2

2.3

CD44

CD44 molecule (Indian blood group), TV5

NM_001001392.1

2.3

LOC100131139

LOC100131140

XR_037336.1

2.3

CBS

Systathionine-beta-synthase

NM_000071.2

2.3

NT5DC2

5'-nucleotidase domain containing 2

NM_022908.2

2.3

NPFFR2

Neuropeptide FF receptor 2

NM_004885.2

2.3

LOC100129685

LOC100129686

XM_001723814.1

2.3

LXN

Latexin

NM_020169.3

2.3

MEX3B

Mex-3 homolog B

NM_032246.3

2.3

C1orf54

Chromosome 1 open reading frame 54

NM_024579.3

2.3

HDDC2

HD domain containing 2

NM_016063.2

2.3

LOC648823

LOC648824

XM_943477.1

2.3

CYB5A

Cytochrome b5 type A

NM_001914.3

2.3

PIR

Pirin (iron binding nuclear protein)

NM_001018109.2

2.3

GPR37

G protein-coupled receptor 37

NM_005302.2

2.3

PPAPDC1A

Phosphatidic acid phosphatase type 2 domain containing 1A

NM_001030059.1

2.3

CD44

CD44 molecule (Indian blood group), TV4

NM_001001391.1

2.2

LOC100131905

LOC100131906

XR_039334.1

2.2

CTAG1A

Cancer/testis antigen 1A

NM_139250.1

2.2

C4orf18

Chromosome 4 open reading frame 18

NM_016613.6

2.2

LDOC1

Leucine zipper, down-regulated in cancer 1

NM_012317.2

2.2

TGFBI

Transforming growth factor, beta-induced

NM_000358.2

2.2

COL5A2

Collagen, type V, alpha 2

NM_000393.3

2.2

NOX4

NADPH oxidase 4

NM_016931.3

2.2

TSHZ3

Teashirt zinc finger homeobox 3

NM_020856.2

2.2

FNDC3B

Fibronectin type III domain containing 3B, TV2

NM_001135095.1

2.2

KIT

V-kit

NM_001093772.1

2.2

ADAM19

ADAM metallopeptidase domain 19

NM_033274.3

2.2

JAM3

Junctional adhesion molecule 3

NM_032801.4

2.1

CGNL1

Cingulin-like 1

NM_032866.4

2.1

COL4A6

Collagen, type IV, alpha 6

NM_001847.2

2.1

BMX

BMX non-receptor tyrosine kinase

NM_001721.6

2.1

DUSP23

Dual specificity phosphatase 23

NM_017823.3

2.1

MMP2

Matrix metallopeptidase 2

NM_004530.4

2.1

NCAPD2

Non-SMC condensin I complex, subunit D2

NM_014865.3

2.1

CYBRD1

Cytochrome b reductase 1, TV1

NM_024843.2

2.1

FAM89A

Family with sequence similarity 89, member A

NM_198552.2

2.1

GAS6

Growth arrest-specific 6

NM_000820.2

2.1

S100A13

S100 calcium binding protein A13

NM_001024211.1

2.1

SMARCE1

SWI/SNF related, subfamily e, member 1

NM_003079.4

2.1

LOC643977

LOC643978

XM_932991.1

2.1

LFNG

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

NM_001040167.1

2.1

MTMR11

Myotubularin related protein 11

NM_181873.3

2.1

ITGA10

Integrin, alpha 10

NM_003637.3

2.1

PTGFRN

Prostaglandin F2 receptor negative regulator

NM_020440.2

2.0

LOC644936

Actin, beta pseudogene

NR_004845.1

2.0

CPS1

Carbamoyl-phosphate synthase 1, mitochonfrial

NM_001875.4

2.0

C18orf56

Chromosome 18 open reading frame 56

NM_001012716.2

2.0

ADA

Adenosine deaminase

NM_000022.2

2.0

NETO2

Neuropilin and tolliod-like2

NM_018092.4

2.0

DKFZp761P0423

DKFZp761P0424

XM_291277.4

2.0

STC2

Stanniocalcin 2

NM_003714.2

2.0

PRKAR1A

Protein kinase, cAMP-dependent, regulatory, type I, alpha

NM_002734.3

2.0

EGFLAM

EGF-like, fibronectin type III and laminin G domains

NM_182801.2

2.0

SPECC1

Sperm antigen with calponin homology, coiled-coil domains 1

NM_001033555.2

2.0

FNDC3B

Fibronectin type III domain containing 3B, TV1

NM_022763.3

2.0

THOC3

THO complex 3

NM_032361.2

2.0

COL5A1

Collagen, type V, alpha 1

NM_000093.3

2.0

LANCL1

LanC lantibiotic synthetase component C-like 1

NM_006055.2

2.0

OCIAD2

OCIA domain containing 2, TV1

NM_001014446.1

2.0

LRIG1

Leucine-rich repeats and immunoglobulin-like domains 1

NM_015541.2

2.0

HOXB2

Homeobox B2

NM_002145.3

2.0

TIMP1

TIMP metallopeptidase inhibitor 1

NM_003254.2

−2.0

NAAA

N-acylethanolamine acid amidase

NM_014435.3

−2.0

MAOA

Monoamine oxidase A

NM_000240.2

−2.0

MYOF

Myoferlin

NM_013451.3

−2.0

KISS1

KiSS metastasis-suppressor

NM_002256.3

−2.0

SLC25A22

Solute carrier family 25, member 22

NM_024698.5

−2.0

NOSIP

Nitric oxide synthase interacting protein

NM_015953.3

−2.0

COL1A2

Collagen, type I, alpha 2

NM_000089.3

−2.0

ZDHHC14

Zinc finger, DHHC-type containing 14

NM_024630.2

−2.0

HPCAL1

Hippocalcin-like 1

NM_134421.1

−2.0

VLDLR

Very low density lipoprotein receptor

NM_001018056.1

−2.0

LOC730525

LOC730525

XM_001126202.1

−2.0

BMP2

Bone morphogenetic protein 2

NM_001200.2

−2.0

ABLIM1

Actin binding LIM protein 1

NM_006720.3

−2.0

PIK3C2A

Phosphoinositide-3-kinase, class 2, alpha polypeptide

NM_002645.2

−2.0

IRF1

Interferon regulatory factor 1

NM_002198.2

−2.0

MBP

Myelin basic protein

NM_001025100.1

−2.0

PRKAR1B

Protein kinase, cAMP-dependent, regulatory type I, beta

NM_002735.2

−2.1

FAM101B

Family with sequence similarity 101, member B

NM_182705.2

−2.1

ERCC2

DNA excision repair protein 2

NM_000400.3

−2.1

CCND2

Cyclin D2

NM_001759.3

−2.1

HLA-B

Major histocompatibility complex, class I, B

NM_005514.6

−2.1

SYBU

Syntabulin

NM_001099743.1

−2.1

PDE2A

Phosphodiesterase 2A, cGMP-stimulated

NM_002599.4

−2.1

AKAP12

A kinase anchor protein 12

NM_005100.3

−2.1

CLEC2B

C-type lectin domain family 2, member B

NM_005127.2

−2.1

S100A4

S100 calcuim binding protein A4

NM_019554.2

−2.1

FST

Follistain

NM_013409.2

−2.2

SLC30A3

Solute carrier family 30, member 3

NM_003459.4

−2.2

PLIN2

Perilipin 2

NM_001122.3

−2.2

IL32

Interleukin 32

NM_001012633.1

−2.2

LOC100128252

LOC100128253

XM_001725603.1

−2.2

TIMM22

Translocase of inner mitochondrial membrane 22 homolog

NM_013337.2

−2.2

SYNM

Synemin, intermediate filament protein

NM_015286.5

−2.2

LOC729985

LOC729986

XM_001131964.1

−2.2

ADRB2

Adrenergic, beta-2-, receptor surface

NM_000024.5

−2.2

KIAA1274

KIAA1274

NM_014431.2

−2.2

PRR5

Proline rich 5

NM_001017529.2

−2.2

LOC387841

LOC387842

XM_932678.1

−2.3

CFI

Complement factor I

NM_000204.3

−2.3

LOC646836

LOC646837

XM_001718162.1

−2.3

COL1A1

Collagen, type I, alpha 1

NM_000088.3

−2.3

CCL2

Chemokine (C-C motif) ligand 2

NM_002982.3

−2.3

COL6A1

Collagen, type VI, alpha 1

NM_001848.2

−2.3

LOC201651

LOC201652

XR_017321.2

−2.3

GALNTL4

GalNAc-T-like protein 4

NM_198516.2

−2.3

S100A3

S100 calcuim binding protein A3

NM_002960.1

−2.4

ALDH1A1

Aldehyde dehydrogenase 1 family, member A1

NM_000689.4

−2.4

TNFRSF14

Tumor necosis factor receptor superfamily, member 14

NM_003820.2

−2.4

CAV1

Caveolin 1

NM_001753.4

−2.4

LAMC2

Laminin, gamma 2

NM_005562.2

−2.4

NOSTRIN

Nitric oxide synthase trafficker

NM_052946.3

−2.4

CEACAM1

Carcinoembryonic antigen-related cell adhesion molecule 1

NM_001024912.2

−2.4

CYYR1

Cysteine/tyrosine-rich 1

NM_052954.2

−2.5

SLC22A23

Solute carrier family 22, member 23

NM_021945.5

−2.5

ACSL5

Acyl-CoA synthetase long-chain family member 5

NM_016234.3

−2.5

AADAC

Arylacetamide deacetylase

NM_001086.2

−2.6

COLEC12

Collectin sub-family member 12

NM_130386.2

−2.6

KIAA1324L

KIAA1324-like

NM_152748.3

−2.6

RNASET2

Ribonuclease T2

NM_003730.4

−2.6

NXN

Nucleoredoxin

NM_022463.4

−2.6

PLA2G4C

Phospholipase A2, group IVC

NM_003706.2

−2.6

SERPINB2

Serpin peptidase inhibitor, clade B, member 2

NM_002575.2

−2.6

CETP

Cholesteryl ester transfer protein, plasma

NM_000078.2

−2.7

PLA2G16

Phospholipase A2, group XVI

NM_007069.3

−2.7

TNFSF18

Tumor necrosis factor superfamily, member 18

NM_005092.3

−2.8

CITED2

Cbp/p300-interacting transactivator 2

NM_006079.3

−2.8

C10orf116

Chromosome 10 open reading fame 116

NM_006829.2

−2.8

PROX1

Prospero homeobox 1

NM_002763.3

−2.9

PALM

Paralemmin

NM_002579.2

−2.9

ZSCAN18

Zinc finger and SCAN domain containing 18

NM_023926.4

−2.9

LEPREL1

Leprecan-like 1

NM_018192.3

−2.9

CTSH

Cathepsin H

NM_004390.3

−2.9

KHDRBS3

RNA-binding protein T-Star

NM_006558.1

−3.0

CDH11

Cadherin 11, type 2, OB-cadherin

NM_001797.2

−3.1

DDIT4L

DNA-damage-inducible transcript 4-like

NM_145244.3

−3.2

GAPDHL6

GAPDHL7

XM_001726954.1

−3.2

NR5A2

Nuclear receptor subfamily 5, group A, member 2

NM_003822.3

−3.3

ABCA3

ATP-binding cassette, sub-family A, member 3

NM_001089.2

−3.3

MARCH2

Membrane-associated ring finger 2

NM_001005416.1

−3.3

CDKN2A

Cyclin-dependent kinase inhibitor 2A

NM_000077.4

−3.3

MGP

Matrix Gla protein

NM_000900.3

−3.3

ALDH1A2

Aldehyde dehydrogenase 1 family, member A2

NM_170697.2

−3.5

HOXB7

Homeobox B7

NM_004502.3

−3.5

EMCN

Endomucin

NM_016242.3

−3.5

ANGPT2

Angiopoietin 2

NM_001147.2

−3.5

GIMAP5

GTPase, IMAP family member 5

NM_018384.4

−3.6

NDN

Necdin homolog

NM_002487.2

−3.8

TACSTD2

Tumor associate calcuim signal transducer 2

NM_002353.2

−3.8

KRT19

Keratin 19

NM_002276.4

−3.8

FAM174B

Family with sequence similarity 174, member B

NM_207446.2

−3.9

CECR1

Cat eye syndrome chromosome region, candidate 1

NM_177405.1

−4.2

GPR116

G protein-coupled receptor 116

NM_015234.4

−4.3

TNFRSF6B

Tumor necrosis factor superfamily, member 6b, decoy

NM_032945.2

−4.3

PIEZO2

Piezo-type mechanosensitive ion channel component 2

NM_022068.2

−4.4

UCHL1

Ubiquitin carboxyl-terminal esterase L1

NM_004181.4

−4.9

KBTBD11

Kelch repeat and BTB domain containing 11

NM_014867.2

−5.3

LOC375295

LOC375296

XM_374020.4

−5.5

HSD17B2

Hydroxysteroid dehydrogenase 2

NM_002153.2

−8.4

LYVE1

Lymphatic vessel endothelial hyaluronan receptor 1

NM_006691.3

−8.8

PDPN

Podoplanin

NM_001006625.1

−15.8

GYPC

Glycophorin C

NM_016815.3

−22.6

MMP1

Matrix metallopeptidase 1

NM_002421.3

−25.8

FABP4

Fatty acid binding protein 4, adipocyte

NM_001442.2

−28.1

CLDN11

Claudin 11

NM_005602.5

−36.9