Table 1 Identification of differentially expressed transcripts between the Colony- or Mature-OECs compared to hCMEC/D3 cells
Symbol | Gene name | Colony-OECs fold change (n=3) | Mature-OECs fold change (n=5) | p value | qvalue |
|---|---|---|---|---|---|
ID3 | Inhibitor of DNA binding 3 | 4.5 ± 0.4 *# | 2.1 ± 1.4 | 0.008 | 0.750 |
TNFAIP2 | Tumor necrosis factor alpha-induced protein 2 | 47.2 (13-455) # | 3.9 (1-9) | 0.018 | 0.750 |
TGFβR1 | Transforming growth factor beta receptor 1 | 3.5 (3-28) # | 1.8 (0.7-2) | 0.030 | 0.750 |
TGFβ1 | Transforming growth factor beta 1 | 2.2 ± 0.2 * | 1.4 ± 0.7 | 0.036 | 0.750 |
CCL2 | Chemokine (C-C motif) ligand 2 | 48.7 (28-117) *# | 12.8 (0.7-20) | 0.036 | 0.500 |
THBS1 | Thrombospondin 1 | 22.7 (19-23) | 5.8 (3-30) * | 0.037 | 0.375 |
BAI 1 | Brain-specific angiogenesis inhibitor 1 | 43 (12-103) | 14.2 (2-33) * | 0.037 | 0.600 |
MMP2 | Matrix metallopeptidase 2 | 508.7 (306-600) * | 67.2 (32-595) * | 0.042 | 0.333 |
NRP2 | Neuropilin 2 | 76.9 (22-185) | 12.7 (9-238) * | 0.043 | 0.300 |
TNF | Tumor necrosis factor | 320.4 (39-531) * | 0.9 (0.5-9) | 0.046 | 0.313 |
IGF1 | Insulin-like growth factor 1 | 11393.9 (1682-13738) *# | 1.4 (0.8-8) | 0.046 | 0.341 |
VEGFC | Vascular endothelial growth factor C | 5.7 (2-6) | 5 (3-9) * | 0.048 | 0.268 |
MMP9 | Matrix metalloprotease 9 | 2125.8 (627-2563)*# | 0.6 (0.1-2) | 0.049 | 0.250 |