Table 1 Summary of different miRs and their roles in vascular cells

Let-7 family

Increases EC proliferation, migration

TIMP-1

[34]

miR-126

Enhances VEGF signaling in ECs

SPRED1, PIK3R2, VCAM-1

[26, 27, 35]

miR-132

Enhances growth factor signaling

p120RasGAP, PTEN

[36, 37]

miR-210

Stimulates tube formation and migration

EphrinA3, NPTX1

[38, 39]

miR-221/222

Inhibits cell proliferation, Anti-angiogenic

C-kit, p27

[25]

miR-296

Inhibits growth factor receptor recycling and degradation

Hepatocyte-growth factor regulated tyrosine kinase substrate

[40]

miR-424

Stablizes HIF-1, proangiogenic

Cullin-2

[41]

miR-92a

Anti-angiogenic. Inhibition enhanced neovascularization in ischemic tissues

ITGA5

[30]

miR-143/145

Critical for VSMC differentiation

KLF4/KLF5

[42]

miR-26a

Increases VSMC proliferation

Smad-1/4

[43]