Figure 1

A simple network of VEGF and Notch signaling regulated by microRNAs. miRs identified in angiogenic screens [36] were cross-referenced with prediction programs for their ability to target specific nodes of a protein interaction network. Several miRs predicted to target angiogenic proteins were significantly downregulated in the screens (blue, italics). The illustration depicts how the loss of a few miRs that target positive regulators of angiogenesis can amplify a pro-angiogenic cascade.