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Figure 2 | Vascular Cell

Figure 2

From: Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis

Figure 2

Combined Notch and VEGF blockade decreases perfusion and branching. (A) Lectin perfusion showed marked reduction in perfusion in NGP-N1D + BV. Bar = 200 μm. (B) Lectin perfusion showed marked reduction in perfusion in NGP-N1D + BV. Error bars represent SD. *P < 0.05. (C) Marked decrease in branches in NGP-LacZ + BV and NGP-N1D + BV. Error bars represent SD. *P < 0.05. (D) Representative H&E of NGP-LacZ + BV and NGP-N1D + BV tumors with coopted glomeruli (black arrowheads). Bar = 100 μm. (E) Compared to NGP-LacZ controls, NGP-LacZ + BV tumors had a higher number of coopted glomeruli per square inch. NGP-N1D tumors were not different from NGP-LacZ controls. NGP-N1D + BV tumors had less coopted glomeruli than NGP-LacZ + BV tumors. Error bars represent SD. *P < 0.05, ***P < 0.001.

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