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Figure 4 | Vascular Cell

Figure 4

From: Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia

Figure 4

Simultaneous administration of VEGF-A and FGF4 stimulates arteriogenesis. (A) NG2-positive pericytes in normo-perfused skeletal muscles 28 days after AAV-mediated muscle transduction. (B) Representative pictures of the double immunofluorescent staining detecting biotinylated lectin B4 Bs bound to endothelial cells (red) and NG2 chondroitin sulfate proteoglycan on pericytes (green). Magnification 400x. (C) The number of arterioles significantly increased in normo-perfused skeletal muscles after AAV-FGF4-IRES-VEGF-A injection in comparison to AAV-LacZ. (D) Representative pictures of α-SMA-positive arterioles (arrows). Magnification 400x. Values are means ± SEM (n = 3/group), * p < 0.05 vs AAV-LacZ.

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