Bisphosphonate-related osteonecrosis of jaw (BRONJ): diagnostic criteria and possible pathogenic mechanisms of an unexpected anti-angiogenic side effect

Table 3 BRONJ: clinical signs and symptoms

Classical sign of BRONJ	Possible clinical signs and symptoms associated but not limited to BRONJ
Exposed necrotic jaw bone	Pain in tooth or bone
	Suppuration
	Swelling
	Sinus and fistula related to jaw bone
	Mobility of teeth
	Trismus
	Non-healing extraction sockets
	Soft tissue ulcerations
	Gross mandibular deformity
	Sequestration of bone

ISSN: 2045-824X