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Figure 5 | Vascular Cell

Figure 5

From: Citicoline induces angiogenesis improving survival of vascular/human brain microvessel endothelial cells through pathways involving ERK1/2 and insulin receptor substrate-1

Figure 5

Immunohistochemical staining for CD31 demonstrated a trend for increased numbers of total microvessels in stroke regions of rats treated with citicoline following MCAO. A) Treatment with citicoline increased the number of CD31-positive microvessels (total number of vessels but did not reach significance) in the peri-infarcted and infarcted regions following transient rat MCAO after 21 days. The figure shows citicoline-treated animals (top row) versus saline treated controls (bottom row). Sections were immunohistochemically stained and developed using DAB (brown). Arrows point to CD31-positively stained microvessels which were morphologically more immature (thinner walls and less pericyte coverage) present in larger numbers in each animal studied following citicoline treatment (n = 3). B) Bar chart showing the increase in CD31 positive and CD105 positive vessels stained in sections (5 analyzed per animal) from rats following transient MCAO and treatment with citicoline as described in the methods section (n = 3 in each group).

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Vascular Cell

ISSN: 2045-824X

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