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Figure 3 | Vascular Cell

Figure 3

From: The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells

Figure 3

AMPK is required for VEGF-stimulated HAEC proliferation. HAECs were incubated in the presence or absence of VEGF-A (10 ng/ml), VEGF-B (100 ng/ml), Compound C (5 μM), STO-609 (5 μM), AICAR (2 mM), A769662 (10 μM), L-NAME (1 mM) for 24 h and proliferation assessed. Ad.control, Ad.AMPK-DN and Ad.AMPK-CA adenoviruses were used to infect HAECs 24 h prior to the addition of VEGF. Results are expressed as the mean ± SEM basal proliferation for three independent experiments or six independent experiments in the case of Ad.AMPK-DN. *p < 0.05 relative to absence of VEGF, **p < 0.05 relative to absence of AICAR or A769662, ***p < 0.05 relative to Ad.control.

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Vascular Cell

ISSN: 2045-824X

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