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Table 1 Temporal changes in NO secretion from control and strained VSMC.

From: Cyclic strain upregulates VEGF and attenuates proliferation of vascular smooth muscle cells

 

Nitric Oxide (nM/ng DNA)

Proliferation Index

 

Time (hours)

Control

Strain

Treatment

[DNA]/(ug/ml)

1

0.13 ± 0.013

0.13 ± 0.014

Control + Ca

6.28 ± 0.69

6

0.09 ± 0.025

0.10 ± 0.016

Strain + Ca

2.98 ± 0.66 **

18

0.12 ± 0.016

0.14 ± 0.013

Strain - Ca

3.30 ± 0.70 *

48

0.07 ± 0.009

0.12 ± 0.013#

Strain + Ca + GdCl3

2.62 ± 0.37 ***

  1. N = 5 per group; #p ≤ 0.05 vs. control at same time point. The effects of strain, calcium-free media and GdCl3 on VSMC proliferation. N = 6; *p < 0.05 vs. Control + Ca, **p < 0.01 vs. Control + Ca, ***p < 0.001 vs. Control + Ca; all values are expressed as mean ± SEM.
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Vascular Cell

ISSN: 2045-824X

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