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Figure 3 | Vascular Cell

Figure 3

From: Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2

Figure 3

Effect of 3ABA on cell-associated plasminogen activator (PA) activity. PA activity was determined spectrophotometrically in untreated HUVEC (Control), and after treatment for 6 and 24 h with FGF2 (10 ng/ml), with FGF2 plus 3ABA (50 μM), with 3ABA. Treatment of cells with FGF2 for 6 and 24 h produced a significative increase in cell-associated PA activity (+60 and 70% respectively) compared to control cells. Values are expressed as International Unit (IU) enzyme/mg protein and are mean ± SEM of four experiments. Multiple comparisons were performed by the Student-Newman-Keuls test, after Kruskal-Wallis analysis. (* p < 0.05 compared to control; # p < 0.05 compared to FGF2 treated cells).

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