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Figure 4 | Vascular Cell

Figure 4

From: A deficiency of uPAR alters endothelial angiogenic function and cell morphology

Figure 4

Actin cytoskeleton organization is circular in uPAR-/- ECs: Lack of uPAR expression induces changes in cell morphology and actin cytoskeleton. Quiescent WT (A, C) and uPAR-/- (B, D) ECs were plated on Vn and allowed to adhere for 4 hr and then stained for actin with phalloidin-FITC. Cells stained for actin (green) and the nucleus (blue) were imaged using a confocal microscope. Images obtained using a 30× objective (A, B) revealed morphological differences between WT and uPAR-/- ECs. Images at higher magnification (100× objective) (C, D) demonstrated that while the WT cells showed polarized actin formation, the uPAR-/- ECs maintained an atypical concentric actin organization.

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