Figure 1

Domain organization of EGFL7. The modular assembly of EGFL7's domains is conserved among vertebrate species. The protein contains an N-terminal signal secretion peptide, an EMI domain, two EGF-like domains (the distal one binds Ca²⁺) and a C-terminal coiled-coil structure. The EGFL7 orthologue CG7447 in Drosophila melanogaster shares the same overall structure but differs in total length.