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Table 4 Randomized clinical studies on transplantation of cells which include endothelial progenitors

From: Endothelial progenitor cells: what use for the cardiologist?

Study/year Disorder N Delivery route Cells delivered Follow-up (months) Effectiveness
Strauer et al. (2002) [117] AMI 20 Intracoronary BM-MNCs 4 Effective
Kang et al. MAGIC (2004) [92] AMI
Old MI
27 Intracoronary PB-MNCs and G-CSF 6 Effective, but high rate of in-stent re-stenosis
Schachinger et al. TOPCARE-AMI (2004) [118] AMI 59 Intracoronary PB-MNCs or BM-MNCs 12 Effective
Ruan et al. (2005) [119] Acute MI 20 Intracoronary BM-MNCs 6 Effective
Strauer et al. IACT (2005) [120] Chronic CAD 36 Intracoronary BM-MNCs 3 Effective
Bartunek et al. (2005) [111] Recent MI 35 Intracoronary CD133+ 4 Effective
Erbs et al. (2005) [112] Chronic CAD 26 Intracoronary Cultured PB-EPCs 3 Effective
Assmus et al. (2006) [111] Chronic CAD 53 Intracoronary BM-MNCs 3 Effective
Meyer et al. BOOST (2006) [104] Acute MI 60 Intracoronary BM-MNCs 18 Effective at 6 month, ineffective at 18 month
Hendrikx et al. (2006) [121] Heart failure 20 Intramyocardial BM-MNCs 4 Ineffective
Janssens et al. (2006) [105] MI 67 Intracoronary BM-MNCs 4 Ineffective
Kang et al. MAGIC Cell-3-DES (2006) [60] Acute MI
Old MI
82 Intracoronary PB-MNCs and G-CSF 6 Effective
Schachinger et al. REPAIR-AMI (2006) [106, 122] AMI 201 Intracoronary BM-MNCs 12 Effective
Ge et al. TCT-STAMI (2006) [95] MI 20 Intracoronary BM-MNCs 6 Effective
Meluzin et al. (2007) [122] Acute MI 60 Intracoronary BM-MNCs 12 Effective
  1. AMI - acute myocardial infarction, BM - bone marrow, CAD - coronary artery disease, G-CSF - granulocyte-colony stimulating factor, MI - myocardial infarction, MNC - mononuclear cell, PB - peripheral blood.