Endothelial progenitor cells: what use for the cardiologist?

Vascular Cell

Table 4 Randomized clinical studies on transplantation of cells which include endothelial progenitors

Study/year	Disorder	N	Delivery route	Cells delivered	Follow-up (months)	Effectiveness
Strauer et al. (2002) [117]	AMI	20	Intracoronary	BM-MNCs	4	Effective
Kang et al. MAGIC (2004) [92]	AMI Old MI	27	Intracoronary	PB-MNCs and G-CSF	6	Effective, but high rate of in-stent re-stenosis
Schachinger et al. TOPCARE-AMI (2004) [118]	AMI	59	Intracoronary	PB-MNCs or BM-MNCs	12	Effective
Ruan et al. (2005) [119]	Acute MI	20	Intracoronary	BM-MNCs	6	Effective
Strauer et al. IACT (2005) [120]	Chronic CAD	36	Intracoronary	BM-MNCs	3	Effective
Bartunek et al. (2005) [111]	Recent MI	35	Intracoronary	CD133+	4	Effective
Erbs et al. (2005) [112]	Chronic CAD	26	Intracoronary	Cultured PB-EPCs	3	Effective
Assmus et al. (2006) [111]	Chronic CAD	53	Intracoronary	BM-MNCs	3	Effective
Meyer et al. BOOST (2006) [104]	Acute MI	60	Intracoronary	BM-MNCs	18	Effective at 6 month, ineffective at 18 month
Hendrikx et al. (2006) [121]	Heart failure	20	Intramyocardial	BM-MNCs	4	Ineffective
Janssens et al. (2006) [105]	MI	67	Intracoronary	BM-MNCs	4	Ineffective
Kang et al. MAGIC Cell-3-DES (2006) [60]	Acute MI Old MI	82	Intracoronary	PB-MNCs and G-CSF	6	Effective
Schachinger et al. REPAIR-AMI (2006) [106, 122]	AMI	201	Intracoronary	BM-MNCs	12	Effective
Ge et al. TCT-STAMI (2006) [95]	MI	20	Intracoronary	BM-MNCs	6	Effective
Meluzin et al. (2007) [122]	Acute MI	60	Intracoronary	BM-MNCs	12	Effective

AMI - acute myocardial infarction, BM - bone marrow, CAD - coronary artery disease, G-CSF - granulocyte-colony stimulating factor, MI - myocardial infarction, MNC - mononuclear cell, PB - peripheral blood.

ISSN: 2045-824X