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Table 1 Effects of cardiovascular risk factors on EPC number and function

From: Endothelial progenitor cells: what use for the cardiologist?

Cardiovascular risk factors Effect on EPC number and function EPC category References
Hypercholesterolemia Reduced EPC number, impaired EPC migratory capacity Circulating EPCs (CD133, 34, 45)
CFU-ECs
[9, 23]
Diabetes Mellitus Reduced EPC number, impaired EPC migratory capacity Circulating EPCs (CD31, 34, KDR)
CFU-ECs
[26, 27, 29, 30]
Hypertension Inverse relationship of EPC number with systolic blood pressure Circulating EPCs (CD133, 34, KDR) [9, 34]
Smoking Affects EPC number in a dose-dependent manner Circulating EPCs (CD133, 34, KDR)
CFU-ECs
[35, 36]
Ageing Reduced migration and proliferation Circulating EPCs (CD133, 34, 45)
CFU-ECs
[1014, 113]
Exercise Increased EPC number and function Circulating EPCs (CD133, 34, 45)
CFU-ECs
[15, 1720]
  1. EPC - endothelial progenitor cells