Figure 3
From: Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors
Isobologram analysis indicating a lack of synergy of naltrexone with temsirolimus on VEGF-induced human EC proliferation and migration. Panel A: Isobologram analysis of the combination of naltrexone and temsirolimus on inhibition of VEGF-induced proliferation. The dashed line indicates a zero interaction for the isobole. The close proximity of the data with the dashed line indicates there is not a synergistic interaction. Panel B: Isobologram analysis of the combination of naltrexone and temsirolimus on inhibition of VEGF-induced migration. The dashed line indicates a zero interaction for the isobole. The close proximity of the data with the dashed line indicates there is not a synergistic interaction.