Figure 4
From: Chloride intracellular channel 1 functions in endothelial cell growth and migration
CLIC1 expression plays a role in the expression of various integrins. Histograms from a typical flow experiment indicate that HUVEC with CLIC1 knockdown (green) had increased β1, α3, and αVβ3 expression and decreased αVβ5 expression while α2 expression remained generally unchanged. Trends persisted despite being cultured on collagen or fibronectin extracellular matrix components. A downward shift in positive control endothelial marker CD31 was typical with CLIC1 knockdown cells.