Tumor growth and angiogenesis is impaired in CIB1 knockout mice

Vascular Cell

Table 1 Melanoma tumors have more gross necrosis in CIB1-KO mice.

Mouse Genotype	Total Number of Mice	Mice with Tumor Necrosis	Mice with No Tumor Necrosis	% of Mice with Tumor Necrosis
B16 Melanoma Tumors^a
WT	9	3	6	33.3%
CIB1-KO	11	7	4	63.6%^b
Lewis Lung Carcinoma Tumors
WT	8	0	8	0.0%
CIB1-KO	9	0	9	0.0%^c

^aTumor necrosis was grossly evident in B16 melanoma tumors that developed in both WT and CIB1-KO mice.
^bThe number of tumors with clear evidence of gross necrosis in CIB1-KO mice was statistically significant (p = 0.05), chi-square test with one degree of freedom.
^cThere was no evidence of gross necrosis in Lewis lung carcinoma tumors that developed in both WT and CIB1-KO mice.

ISSN: 2045-824X