Figure 3

Melanoma in CIB1-KO mice have reduced vascularization. (a) Representative immunoflorescent images of Isolectin GSL1-B4-stained melanoma tumor sections and PECAM-1-stained carcinoma tumor sections. The number of vessels with a clear lumen and < 7 μm in melanoma (b) and carcinoma (c) tumors were counted by a blinded observer. Tumor microvessel density is reported as the average number of intra-tumoral microvessels per frame. Error bars are ± SEM (n = 7 - 11 mice per group; * p < 0.05).